|
[BK21 Plus Seminar]
▶Subject: Myrf: A story of a bioinformatician-turned neurobiologist
▶Speaker: Prof. Yungki Park (Department of Biochemistry, University at Buffalo) ▶Date: 4:00 PM/July 8(Mon.)/2019 ▶Place: Auditorium(1F), Postech Biotech Center
▶Abctract
Myelination of the central nervous system (CNS) is critical to vertebrate nervous systems for efficient neural signaling. CNS myelination occurs as oligodendrocytes (OLs) terminally differentiate, a process regulated in part by the myelin regulatory factor, MYRF. In part I, I will discuss our discovery that Myrf is a membrane-bound transcription factor that undergoes auto-cleavage to release its N-terminal fragment from the endoplasmic reticulum (ER) membrane as a homo-trimer. The homo-trimer of Myrf N-terminal fragments enters the nucleus to exert transcriptional effects. Homo-trimerization is critical to the transcription factor function of Myrf N-terminal fragment because it confers DNA binding specificity. In part II, I will discuss our recent study where we utilized bioinformatics and epigenome editing analysis to uncover two OL enhancers that jointly regulate Myrf expression for the timely development of OLs. ▶Inquiry: Prof. Sung Ho Ryu (279-2292)
* This seminar will be given in English.
Please refrain from taking photos during seminars. *
|
